What areas of research are you involved in?

Traumatic Brain Injury and its link with Dementia, and Posttraumatic Stress Disorder. I am mainly focused on preclinical and translation research. My specific interests are in neuroinflammation, vascular biology and neuroendocrine dysfunction.

In one of my recent studies, we are investigating the therapeutic effect of genetically removing a proinflammatory molecule specifically located in immune cells of the brain following Traumatic Brain Injury. We are examining whether long-term treatment can successfully reduce brain inflammation and the accumulation of toxic proteins found in post-mortem tissue of deceased patients exposed to a history of repetitive brain injuries. Finally, we are also exploring whether this treatment can restore cognitive function and prevent motor- disabilities.

Lab Item Wishlist

How will this equipment benefit your work?

• ScRNA-seq is a powerful tool that captures in unprecedented detail the gene expression profiles of all individual cells in a tissue at high read depth and increasing scalability.
• scRNASeq will enable us the ability to gain a better and deeper understanding of complex highly heterogeneous tissue such as neural tissue or CNS immune systems by providing an unbiased and detailed cell-by-cell molecular as well as cellular characterization at single cell resolution.
• scRNASeq will also be very helpful in analyzing and mapping out rare inflammatory cell populations and their subtypes involved in driving disease pathology and reveal gene regulatory networks and molecular dynamics of such disease associated cell types that could lead to identification of novel targets which can be explored as new therapeutic strategies to repair cellular brain damage after head injury.

Importance of understanding the cellular complexity of brain tissue after injury and conducting well designed preclinical translational research which is a key aspect of drug discovery and development.

YOU CAN MAKE A DIFFERENCE!

You have an opportunity to make a tangible impact in the realm of neuroscience and healthy aging. Our team is dedicated to scientific research with the goal of identifying safe and effective therapies for brain diseases.

By equipping our labs with the latest technology, we can expedite our research efforts significantly. Your support could catalyze groundbreaking discoveries bringing us closer to our vision: “A World Without Brain Disease”.