Joseph Ojo

PhD

Head of Neuropathology

Biography

I am a neuroscientist at the Roskamp Institute with expertise in experimental neuropathology and molecular disease mechanisms. My research focuses on understanding how traumatic brain injury can trigger long-term neurodegenerative conditions, including chronic traumatic encephalopathy and Alzheimer’s disease–related dementias. I use a combination of laboratory models and human brain tissue to investigate how inflammatory and vascular responses after injury drive neurodegeneration and neurological dysfunction. By integrating neuropathology, advanced imaging, and multi-omics approaches, my goal is to identify new therapeutic strategies that reduce chronic inflammation, support brain repair, and slow or prevent progressive neurodegeneration.

Recent Publications

The NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury

Authors: Janeen Laabei, Gloria Vegliante, Nathan Ryzewski Strogulski, Carly Douglas, Sahil Threja, Andrew Pearson, Aurore Nkiliza, Marie Hanscom, Isabella Dias Filogonio Emediato, Fiona Crawford, Joseph Ojo, and David J. Loane

Publish Date: October 27, 2025

PPARγ activation ameliorates cognitive impairment and chronic microglial activation in the aftermath of r-mTBI

Authors: Andrew Pearson, Milica Koprivica, Max Eisenbaum, Camila Ortiz, Mackenzie Browning, Tessa Vincennie, Cooper Tinsley, Michael Mullan, Fiona Crawford, and Joseph Ojo

Publish Date: August 3, 2024

Overexpression of pathogenic tau in astrocytes causes a reduction in AQP4 and GLT1, an immunosuppressed phenotype and unique transcriptional responses to repetitive mild TBI without appreciable changes in tauopathy

Authors: Camila Ortiz, Andrew Pearson, Robyn McCartan, Shawn Roche, Nolan Carothers, Mackenzie Browning, Sylvia Perez, Bin He, Stephen D. Ginsberg, Michael Mullan, Elliott J. Mufson, Fiona Crawford, and Joseph Ojo

Publish Date: May 15, 2024

Repetitive head trauma and apoE4 induce chronic cerebrovascular alterations that impair tau elimination from the brain

Authors: Maxwell Eisenbaum, Andrew Pearson, Camila Ortiz, Milica Koprivica, Arianna Cembran, Michael Mullan, Fiona Crawford, Joseph Ojo, and Corbin Bachmeier

Publish Date: January 30, 2024